Contact guidance in human dermal fibroblasts is modulated by population pressure
Open Access
- 16 June 2005
- journal article
- Published by Wiley in Journal of Anatomy
- Vol. 206 (6), 581-587
- https://doi.org/10.1111/j.1469-7580.2005.00415.x
Abstract
Morphogenesis is underpinned by orientated cell division, motility and growth. The substratum for migrating cells in vivo comprises either extracellular matrix or the surfaces of adjacent cells and both are believed to inform the dynamic behaviour of adherent cells through contact guidance. Collisions between migrating cells in vitro can induce the phenomena of contact inhibition of locomotion and division, suggesting that their sensitivity to substratum-derived cues may also be influenced by population density. In the present study dermal fibroblasts, which are known to be motile in culture and are fundamental to the organization of the extracellular matrix, were used to examine the influence of population pressure on the ability of substratum topography to induce contact guidance. The findings suggest that sensitivity to substratum-derived morphogenetic guidance cues, as revealed by alignment of cells to microtopography, is modulated by population pressure.This publication has 43 references indexed in Scilit:
- Molecular responses of human dermal fibroblasts to dual cues: Contact guidance and mechanical loadCell Motility, 2000
- Synergistic and Hierarchical Adhesive and Topographic Guidance of BHK CellsExperimental Cell Research, 1996
- Are Growth Factors Chemotactic Agents?Experimental Cell Research, 1995
- Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptideDevelopmental Biology, 1989
- New evidence that growth in 3T3 cell cultures is a diffusion-limited processNature, 1984
- Fibroblast-collagen interactions in the formation of the secondary stroma of the chick cornea.The Journal of cell biology, 1977
- Mutual contact inhibition of extension of chick sensory nerve fibres in vitroJournal of Comparative Neurology, 1971
- The locomotory behaviour of small groups of fibroblastsProceedings of the Royal Society of London. B. Biological Sciences, 1965
- Interference microscope studies of cell contacts in tissue cultureExperimental Cell Research, 1958
- The cultivation of tissues in extraneous media as a method of morpho‐genetic studyThe Anatomical Record, 1912