Interrelationships of Hyperinsulinism and Hypertriglyceridemia in Young Patients with Coronary Heart Disease
- 1 December 1968
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 38 (6), 1156-1163
- https://doi.org/10.1161/01.cir.38.6.1156
Abstract
Fasting serum lipid levels, glucose tolerance, and immunoreactive insulin concentrations of 50 young patients with coronary heart disease (CHD) and 30 control subjects were evaluated to study the interrelationships of these metabolic factors. Abnormalities in one or more of these factors could be shown in 90% of the patients and 20% of the control subjects. Thirty-four of the 50 patients had elevated cholesterol or triglyceride levels, or both, 30 had abnormally elevated or delayed insulin responses after glucose, and 17 had abnormal glucose tolerance. A significant correlation existed between serum triglyceride and insulin concentrations. When insulin levels were reduced by phenformin, triglyceride concentrations fell toward normal. These findings indicate that carbohydrate, insulin, and lipid abnormalities are rather prevalent in patients with CHD. Excessive insulin secretion secondary to mild glucose intolerance probably induces hepatic synthesis of triglycerides and hypertriglyceridemia. Dietary alterations or pharmacological agents may help to control some of the metabolic abnormalities associated with premature CHD.Keywords
This publication has 15 references indexed in Scilit:
- Role of Insulin in Endogenous Hypertriglyceridemia*JCI Insight, 1967
- Hyperglyceridemia in Coronary Artery Disease and Its ManagementPublished by American Medical Association (AMA) ,1967
- Insulin Secretion in Response to Glycemic Stimulus: Relation of Delayed Initial Release to Carbohydrate intolerance in Mild Diabetes Mellitus*JCI Insight, 1967
- Glucose, insulin, and triglyceride responses to high and low carbohydrate diets in man.JCI Insight, 1966
- Effect of starch and sucrose on carbohydrate-induced hyperlipaemia.BMJ, 1966
- EFFECT OF SIMPLE AND COMPLEX CARBOHYDRATES ON PLASMA NON-ESTERIFIED FATTY ACIDS, PLASMA-SUGAR, AND PLASMA-INSULIN DURING ORAL CARBOHYDRATE TOLERANCE TESTSThe Lancet, 1966
- PLASMA-INSULIN CONCENTRATIONS AFTER MYOCARDIAL INFARCTIONThe Lancet, 1965
- IDIOPATHIC HYPERLIPEMIA: METABOLIC STUDIES IN AN AFFECTED FAMILY*JCI Insight, 1960
- AN IMMUNOCHEMICAL ASSAY OF TOTAL EXTRACTABLE INSULIN IN MAN *JCI Insight, 1960
- A Rapid and Simple Method for the Determination of Esterified Fatty Acids and for Total Fatty Acids in BloodJournal of Clinical Pathology, 1953