Monocytes and Macrophages in Pregnancy and Pre-Eclampsia
Open Access
- 30 June 2014
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 5, 298
- https://doi.org/10.3389/fimmu.2014.00298
Abstract
Preeclampsia is an important complication in pregnancy, characterized by hypertension and proteinuria in the second half of pregnancy. Generalized activation of the inflammatory response is thought to play a role in the pathogenesis of preeclampsia. Monocytes may play a central role in this inflammatory response. Monocytes are short lived cells, that mature in the circulation and invade into tissues upon an inflammatory stimulus and develop into macrophages. Macrophages are abundantly present in the endometrium and play a role in implantation and placentation in normal pregnancy. In preeclampsia, these macrophages appear to be present in larger numbers and are also activated. In the present review we focused on the role of monocytes and macrophages in the pathophysiology of preeclampsia.Keywords
This publication has 127 references indexed in Scilit:
- Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseasesBiomarker Research, 2014
- Rat placentation: An experimental model for investigating the hemochorial maternal-fetal interfacePlacenta, 2012
- Differential Distribution and Phenotype of Decidual Macrophages in Preeclamptic versus Control PregnanciesThe American Journal of Pathology, 2011
- IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodelingProceedings of the National Academy of Sciences of the United States of America, 2010
- Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver FibrosisPLOS ONE, 2010
- REVIEW ARTICLE: Interleukin‐10: A Multi‐Faceted Agent of PregnancyAmerican Journal of Reproductive Immunology, 2010
- The Global Impact of Pre-eclampsia and EclampsiaSeminars in Perinatology, 2009
- Hypertension in Response to Chronic Reductions in Uterine Perfusion in Pregnant RatsHypertension, 2008
- Gene Expression Profiling of Human Decidual Macrophages: Evidence for Immunosuppressive PhenotypePLOS ONE, 2008
- Monocyte and macrophage heterogeneityNature Reviews Immunology, 2005