Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women
Open Access
- 4 June 2009
- Vol. 115 (12), 2765-2774
- https://doi.org/10.1002/cncr.24328
Abstract
BACKGROUND: Circulating estrogens and androgens are important factors in the development of various female cancers. Caffeine intake may decrease risk of breast and ovarian cancer, although the data are not entirely consistent. Whether or not caffeine affects cancer risk by altering sex hormone levels is currently unknown. METHODS: We examined the relationship of caffeine, coffee, decaffeinated coffee, and tea with plasma concentrations of estrogens, androgens, progesterone, prolactin, and sex hormone–binding globulin (SHBG) in 524 premenopausal and 713 postmenopausal women from the Nurses' Health Study (NHS) and NHSII. RESULTS: In premenopausal women, caffeine intake was inversely associated with luteal total and free estradiol, and positively associated with luteal progesterone levels (P‐trend = .02, .01, .03, respectively). Coffee intake was significantly associated with lower luteal total and free estradiol levels, but not luteal progesterone levels (P‐trend = .007, .004, .20, respectively). Among the postmenopausal women, there was a positive association between caffeine and coffee intake and SHBG levels (P‐trend = .03 and .06, respectively). No significant associations were detected with the other hormones. CONCLUSIONS: Data from this cross‐sectional study suggest that caffeine may alter circulating levels of luteal estrogens and SHBG, representing possible mechanisms by which coffee or caffeine may be associated with pre‐ and postmenopausal malignancies, respectively. Future studies evaluating how caffeine‐mediated alterations in sex hormones and binding protein levels affect the risk of female cancers are warranted. Cancer 2009. © 2009 American Cancer Society.Keywords
This publication has 37 references indexed in Scilit:
- Coffee, tea, caffeine and risk of breast cancer: A 22‐year follow‐upInternational Journal of Cancer, 2008
- Tea and coffee drinking and ovarian cancer risk: results from the Netherlands Cohort Study and a meta-analysisBritish Journal of Cancer, 2007
- Endogenous Androgens and Risk of Epithelial Ovarian Cancer: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC)Cancer Epidemiology, Biomarkers & Prevention, 2007
- Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer Among Premenopausal WomenJNCI Journal of the National Cancer Institute, 2006
- Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer: Does the Association Vary by a Woman's Predicted Breast Cancer Risk?Journal of Clinical Oncology, 2006
- Serum Sex Steroids in Premenopausal Women and Breast Cancer Risk Within the European Prospective Investigation into Cancer and Nutrition (EPIC)JNCI Journal of the National Cancer Institute, 2005
- Plasma Sex Hormone Concentrations and Subsequent Risk of Breast Cancer Among Women Using Postmenopausal HormonesJNCI Journal of the National Cancer Institute, 2005
- Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone‐binding globulin in premenopausal Japanese womenNutrition and Cancer, 1998
- Percentage Points for a Generalized ESD Many-Outlier ProcedureTechnometrics, 1983
- Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperatureJournal of Steroid Biochemistry, 1982