REPRESENTATION of CUTANEOUS AFFERENTS BY FLUORIDE-RESISTANT ACID PHOSPHATASE (FRAP)-ACTIVE TERMINALS IN the RAT SUBSTANTIA GELATINOSA ROLANDI

Abstract
While transection of the sciatic nerve resulted in a complete ipsilateral extinction of FRAP activity in respective segments of the rat spinal cord, cutaneous denervation of the hind leg induced a patchy disappearance of this same enzyme in the Rolando substance. The possible participation of FRAP in metabolism of the primary sensory transmitter substance, its relation to substance P and its involvement in gating mechanisms were discussed.