tRNA Modification and Genetic Code Variations in Animal Mitochondria
Open Access
- 1 January 2011
- journal article
- Published by Hindawi Limited in Journal of Nucleic Acids
- Vol. 2011, 1-12
- https://doi.org/10.4061/2011/623095
Abstract
In animal mitochondria, six codons have been known as nonuniversal genetic codes, which vary in the course of animal evolution. They are UGA (termination codon in the universal genetic code changes to Trp codon in all animal mitochondria), AUA (Ile to Met in most metazoan mitochondria), AAA (Lys to Asn in echinoderm and some platyhelminth mitochondria), AGA/AGG (Arg to Ser in most invertebrate, Arg to Gly in tunicate, and Arg to termination in vertebrate mitochondria), and UAA (termination to Tyr in a planaria and a nematode mitochondria, but conclusive evidence is lacking in this case). We have elucidated that the anticodons of tRNAs deciphering these nonuniversal codons ( for UGA, for AUA, for AAA, and and for AGA/AGG) are all modified; has 5-carboxymethylaminomethyluridine or 5-taurinomethyluridine, has 5-formylcytidine or 5-taurinomethyluridine, has 7-methylguanosine and has 5-taurinomethyluridine in their anticodon wobble position, and has pseudouridine in the anticodon second position. This review aims to clarify the structural relationship between these nonuniversal codons and the corresponding tRNA anticodons including modified nucleosides and to speculate on the possible mechanisms for explaining the evolutional changes of these nonuniversal codons in the course of animal evolution.Keywords
This publication has 54 references indexed in Scilit:
- Taurine-containing Uridine Modifications in tRNA Anticodons Are Required to Decipher Non-universal Genetic Codes in Ascidian Mitochondria*Online Journal of Public Health Informatics, 2011
- Unconventional decoding of the AUA codon as methionine by mitochondrial tRNA Met with the anticodon f 5 CAU as revealed with a mitochondrial in vitro translation systemNucleic Acids Research, 2009
- A unique genetic code change in the mitochondrial genome of the parasitic nematode Radopholus similisBMC Research Notes, 2009
- mtRF1a Is a Human Mitochondrial Translation Release Factor Decoding the Major Termination Codons UAA and UAGMolecular Cell, 2007
- The Mechanisms of Codon Reassignments in Mitochondrial Genetic CodesJournal of Molecular Evolution, 2007
- Classification of the possible pairs between the first anticodon and the third codon positions based on a simple model assuming two geometries with which the pairing effectively potentiates the decoding complexJournal of Theoretical Biology, 2006
- Dual-mode recognition of noncanonical tRNAsSer by seryl-tRNA synthetase in mammalian mitochondriaThe EMBO Journal, 2005
- A Novel Modified Nucleoside Found at the First Position of the Anticodon of Methionine tRNA from Bovine Liver MitochondriaBiochemistry, 1994
- Nitrogen-15-labeled oligodeoxynucleotides. 3. Protonation of the adenine N1 in the A.cntdot.C and A.cntdot.G mispairs of the duplexes {d[CG(15N1)AGAATTCCCG]}2 and {d[CGGGAATTC(15N1)ACG]}2Journal of the American Chemical Society, 1991
- Codon—anticodon pairing: The wobble hypothesisJournal of Molecular Biology, 1966