Role of the ABC Transporter Mdl1 in Peptide Export from Mitochondria
- 16 March 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 291 (5511), 2135-2138
- https://doi.org/10.1126/science.1056957
Abstract
ATP-binding cassette (ABC) adenosine triphosphatases actively transport a wide variety of compounds across biological membranes. Here, the ABC protein Mdl1 was identified as an intracellular peptide transporter localized in the inner membrane of yeast mitochondria. Mdl1 was required for mitochondrial export of peptides with molecular masses of ∼2100 to 600 daltons generated by proteolysis of inner-membrane proteins by the m-AAA protease in the mitochondrial matrix. Proteolysis by the i-AAA protease in the intermembrane space led to the release of similar-sized peptides independent of Mdl1. Thus, two pathways of peptide efflux from mitochondria exist that may allow communication between mitochondria and their cellular environment.Keywords
This publication has 26 references indexed in Scilit:
- MTABC3, a Novel Mitochondrial ATP-binding Cassette Protein Involved in Iron HomeostasisPublished by Elsevier BV ,2000
- Identification and Characterization of YME1L1, a Novel Paraplegin-Related GeneGenomics, 2000
- Footprints of aminoacyl-tRNA synthetases are everywhereTrends in Biochemical Sciences, 2000
- Membrane Protein Degradation by AAA Proteases in Mitochondria: Extraction of Substrates from Either Membrane SurfaceMolecular Cell, 2000
- ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humansJournal of Molecular Biology, 1999
- Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane proteinJournal of Molecular Biology, 1999
- Afg3p, a mitochondrial ATP‐dependent metalloprotease, is involved in degradation of mitochondrially‐encoded Cox1, Cox3, Cob, Su6, Su8 and Su9 subunits of the inner membrane complexes III, IV and VFEBS Letters, 1996
- ABC Transporters: From Microorganisms to ManAnnual Review of Cell Biology, 1992
- The ‘ins’ and ‘outs’ of mitochondrial membrane channelsTrends in Biochemical Sciences, 1992
- ABC Transporters: From Mircoorganisms to ManAnnual Review of Cell and Developmental Biology, 1992