Modulating Hox gene functions during animal body patterning
- 10 November 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Genetics
- Vol. 6 (12), 893-904
- https://doi.org/10.1038/nrg1726
Abstract
With their power to shape animal morphology, few genes have captured the imagination of biologists as the evolutionarily conserved members of the Hox clusters have done. Recent research has provided new insight into how Hox proteins cause morphological diversity at the organismal and evolutionary levels. Furthermore, an expanding collection of sequences that are directly regulated by Hox proteins provides information on the specificity of target-gene activation, which might allow the successful prediction of novel Hox-response genes. Finally, the recent discovery of microRNA genes within the Hox gene clusters indicates yet another level of control by Hox genes in development and evolution.Keywords
This publication has 92 references indexed in Scilit:
- Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitaliaDevelopment, 2005
- Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capabilityDevelopmental Biology, 2005
- WebLogo: A Sequence Logo Generator: Figure 1Genome Research, 2004
- The Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory elementBiochemical and Biophysical Research Communications, 2004
- Prediction of Mammalian MicroRNA TargetsCell, 2003
- TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulationDevelopmental Dynamics, 2003
- The Drosophila Hox Gene Deformed Sculpts Head Morphology via Direct Regulation of the Apoptosis Activator reaperCell, 2002
- dlarp, a new candidateHox target inDrosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactionsDevelopmental Dynamics, 2000
- Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39Cell, 1993
- Genetic analysis of the homeotic gene complex (HOM-C) in the beetle Tribolium castaneumDevelopmental Biology, 1989