Mechanism and evolution of the uncoupling protein of brown adipose tissue
- 31 March 1990
- journal article
- research article
- Published by Elsevier BV in Trends in Biochemical Sciences
- Vol. 15 (3), 108-112
- https://doi.org/10.1016/0968-0004(90)90194-g
Abstract
The uncoupling protein found in mitochondria from thermogenic brown adipose tissue is structurally very similar to two other mitochondrial carrier proteins transporting ADP/ATP and phosphate, respectively. Similarities are also seen with the mechanism of these carriers, which are part of a family of H+/OH−-substrate anion co-transporters, further strengthening the evidence that the uncoupling protein has evolved from this family of mitochondrial carrier proteins.Keywords
This publication has 22 references indexed in Scilit:
- Solute carriers involved in energy transfer of mitochondria form a homologous protein familyFEBS Letters, 1987
- Light-driven protonation changes of internal aspartic acids of bacteriorhodopsin: an investigation of static and time-resolved infrared difference spectroscopy using [4-13C]aspartic acid labeled purple membraneBiochemistry, 1985
- Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondriaBiochemistry, 1982
- Isolation of the uncoupling protein from brown adipose tissue mitochondriaFEBS Letters, 1980
- Brown adipose tissue mitochondriaBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1979
- Brown‐Adipose‐Tissue Mitochondria: Photoaffinity Labelling of the Regulatory Site of Energy DissipationEuropean Journal of Biochemistry, 1978
- The Effective Proton Conductance of the Inner Membrane of Mitochondria from Brown Adipose TissueEuropean Journal of Biochemistry, 1977
- Binding of guanine nucleotides to the outer surface of the inner membrane of guinea pig brown fat mitochondria in correlation with the thermogenic activity of the tissueFEBS Letters, 1976
- Hamster Brown‐Adipose‐Tissue MitochondriaEuropean Journal of Biochemistry, 1976
- Hamster Brown‐Adipose‐Tissue MitochondriaEuropean Journal of Biochemistry, 1974