Endemic Tegumentary Leishmaniasis in Brazil: Correlation between Level of Endemicity and Number of Cases of Mucosal Disease
- 1 June 2011
- journal article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 84 (6), 901-905
- https://doi.org/10.4269/ajtmh.2011.10-0595
Abstract
The purpose of this study was to establish a correlation between the endemic level of tegumentary leishmaniasis in different regions of Brazil during 2002-2009 and the number of cases of mucosal or mucocutaneous leishmaniasis. The proportion of mucosal leishmaniasis was inversely correlated with prevalence of infection. In areas with a lower infection prevalence, the proportion of mucosal leishmaniasis increased (P < 0.05). The hypothesis of an Amazonian origin and dissemination through human migration is considered. Our results show that in regions with lower prevalence and endemically younger, the proportion of cases that evolve to the mucosal form is higher than in regions with higher prevalence and endemically older.This publication has 30 references indexed in Scilit:
- kDNA minicircle signatures of Leishmania (Viannia) braziliensis in oral and nasal mucosa from mucosal leishmaniasis patientsDiagnostic Microbiology and Infectious Disease, 2010
- Identificação de espécies de Leishmania isoladas de casos humanos em Mato Grosso do Sul por meio da reação em cadeia da polimeraseRevista da Sociedade Brasileira de Medicina Tropical, 2009
- Primary laryngeal leishmaniasis: A rare case reportIndian Journal of Pathology and Microbiology, 2009
- Recent developments leading toward a paradigm switch in the diagnostic and therapeutic approach to human leishmaniasisCurrent Opinion in Infectious Diseases, 2008
- Evidence forLeishmania (Viannia)Parasites in the Skin and Blood of Patients Before and After TreatmentThe Journal of Infectious Diseases, 2006
- Modelagem espacial de zonas de risco da leishmaniose tegumentar americanaRevista de Saúde Pública, 2004
- Sobre a origem e dispersão das leishmanioses cutânea e mucosa com base em fontes históricas pré e pós-colombianasHistória, Ciências, Saúde-Manguinhos, 2003
- Genetic variation in populations of Leishmania species in BrazilTransactions of the Royal Society of Tropical Medicine and Hygiene, 2002
- Mucosal leishmaniasis ("espundia") responsive to low dose of N-methyl glucamine (Glucantime ®) in Rio de Janeiro, BrazilRevista do Instituto de Medicina Tropical de São Paulo, 2000
- Genomic rearrangements in trypanosomatids: an alternative to the "one gene" evolutionary hypotheses?Memórias do Instituto Oswaldo Cruz, 2000