Xenograft and organoid model systems in cancer research
Top Cited Papers
Open Access
- 8 July 2019
- journal article
- review article
- Published by Springer Science and Business Media LLC in The EMBO Journal
- Vol. 38 (15), e101654
- https://doi.org/10.15252/embj.2019101654
Abstract
Patient‐derived tumour xenografts and tumour organoids have become important preclinical model systems for cancer research. Both models maintain key features from their parental tumours, such as genetic and phenotypic heterogeneity, which allows them to be used for a wide spectrum of applications. In contrast to patient‐derived xenografts, organoids can be established and expanded with high efficiency from primary patient material. On the other hand, xenografts retain tumour–stroma interactions, which are known to contribute to tumorigenesis. In this review, we discuss recent advances in patient‐derived tumour xenograft and tumour organoid model systems and compare their promises and challenges as preclinical models in cancer research.Keywords
Funding Information
- KWF Kankerbestrijding (10218)
This publication has 102 references indexed in Scilit:
- A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic ScreeningCell Stem Cell, 2018
- Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancerScience, 2017
- A patient-derived-xenograft platform to study BRCA-deficient ovarian cancersJCI Insight, 2017
- Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer PatientsCell, 2015
- Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human LiverCell, 2014
- Organoid Cultures Derived from Patients with Advanced Prostate CancerCell, 2014
- Humanized mice for immune system investigation: progress, promise and challengesNature Reviews Immunology, 2012
- A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal CancerCancer Discovery, 2011
- G-CSF supplementation with chemotherapy can promote revascularization and subsequent tumor regrowth: prevention by a CXCR4 antagonistBlood, 2011
- Molecular Target Class Is Predictive of In vitro Response ProfileCancer Research, 2010