Wnt signaling meets internal dissent: Figure 1.
- 1 September 2011
- journal article
- comment
- Published by Cold Spring Harbor Laboratory in Journal of Bone and Joint Surgery
- Vol. 25 (17), 1759-1762
- https://doi.org/10.1101/gad.17594311
Abstract
In canonical Wnt signaling, β-catenin translocates to the cell nucleus, interacting with Tcf/Lef factors to activate transcription of Wnt target genes. In this issue of Genes & Development, Vacik and colleagues (pp. 1783–1795) report that a highly conserved sequence in intron 5 of Tcf7l2 conceals an internal promoter region that, when activated by Vax2, drives transcription of truncated Tcf7l2 mRNAs. The encoded Tcf7l2 protein binds to DNA, but not β-catenin, and therefore acts as a dominant-negative Wnt antagonist.Keywords
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