Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations
- 15 November 2008
- journal article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 178 (10), 1017-1022
- https://doi.org/10.1164/rccm.200801-182oc
Abstract
Asthma prevalence and severity are high among underserved minorities, including those of African descent. The Duffy antigen/receptor for chemokines is the receptor for Plasmodium vivax on erythrocytes and functions as a chemokine-clearing receptor. Unlike European populations, decreased expression of the receptor on erythrocytes is common among populations of African descent, and results from a functional T-46C polymorphism (rs2814778) in the promoter. This variant provides an evolutionary advantage in malaria-endemic regions, because Duffy antigen/receptor for chemokines-negative erythrocytes are more resistant to infection by P. vivax. To determine the role of the rs2814778 polymorphism in asthma and atopy as measured by total serum IgE levels among four populations of African descent (African Caribbean, African American, Brazilian, and Colombian) and a European American population. Family-based association tests were performed in each of the five populations to test for association between the rs2814778 polymorphism and asthma or total IgE concentration. Asthma was significantly associated with the rs2814778 polymorphism in the African Caribbean, Colombian, and Brazilian families (P < 0.05). High total IgE levels were associated with this variant in African Caribbean and Colombian families (P < 0.05). The variant allele was not polymorphic among European Americans. Susceptibility to asthma and atopy among certain populations of African descent is influenced by a functional polymorphism in the gene encoding Duffy antigen/receptor for chemokines. This genetic variant, which confers resistance to malarial parasitic infection, may also partially explain ethnic differences in morbidity of asthma.Keywords
This publication has 56 references indexed in Scilit:
- Duffy Antigen Receptor for Chemokines Mediates trans-Infection of HIV-1 from Red Blood Cells to Target Cells and Affects HIV-AIDS SusceptibilityCell Host & Microbe, 2008
- A NOS1 Gene Polymorphism Associated with Asthma and Specific Immunoglobulin E Response to Mite Allergens in a Colombian PopulationInternational Archives of Allergy and Immunology, 2007
- Identification of mouse Duffy Antigen Receptor for Chemokines (Darc) as a BMD QTL geneGenome Research, 2007
- Admixture dynamics in Hispanics: A shift in the nuclear genetic ancestry of a South American population isolateProceedings of the National Academy of Sciences of the United States of America, 2006
- A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of AsthmaHuman Genetics, 2004
- Prevalence of asthma symptoms in Latin America: The international study of asthma and allergies in childhood (ISAAC)Pediatric Pulmonology, 2000
- Detection of the Signature of Natural Selection in Humans: Evidence from the Duffy Blood Group LocusAmerican Journal of Human Genetics, 2000
- Estimating African American Admixture Proportions by Use of Population-Specific AllelesAmerican Journal of Human Genetics, 1998
- Ethnic Differences in the Prevalence of Asthma in Middle Class ChildrenAnnals of Allergy, Asthma & Immunology, 1997
- Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy–negative individualsNature Genetics, 1995