Support for involvement of neuregulin 1 in schizophrenia pathophysiology
- 16 November 2004
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Molecular Psychiatry
- Vol. 10 (4), 366-374
- https://doi.org/10.1038/sj.mp.4001608
Abstract
Schizophrenia is a common, multigenic psychiatric disorder. Linkage studies, including a recent meta-analysis of genome scans, have repeatedly implicated chromosome 8p12-p23.1 in schizophrenia susceptibility. More recently, significant association with a candidate gene on 8p12, neuregulin 1 (NRG1), has been reported in several European and Chinese samples. We investigated NRG1 for association in schizophrenia patients of Portuguese descent to determine whether this gene is a risk factor in this population. We tested NRG1 markers and haplotypes for association in 111 parent-proband trios, 321 unrelated cases, and 242 control individuals. Associations were found with a haplotype that overlaps the risk haplotype originally reported in the Icelandic population (‘HapICE’), and two haplotypes located in the 3′ end of NRG1 (all PICE itself. Comparison of NRG1 transcript expression in peripheral leukocytes from schizophrenia patients and unaffected siblings identified 3.8-fold higher levels of the SMDF variant in patients (P=0.039). Significant positive correlations (PNRG1 and multiple NRG1 variants are involved in schizophrenia.Keywords
This publication has 45 references indexed in Scilit:
- Genome-wide scan in Portuguese Island families identifies 5q31–5q35 as a susceptibility locus for schizophrenia and psychosisMolecular Psychiatry, 2003
- Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: SchizophreniaAmerican Journal of Human Genetics, 2003
- Neuregulin 1 and Susceptibility to SchizophreniaAmerican Journal of Human Genetics, 2002
- Linkage of Familial Schizophrenia to Chromosome 13q32American Journal of Human Genetics, 1999
- A genome-wide search for schizophrenia susceptibility genesAmerican Journal of Medical Genetics, 1998
- Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21Nature Genetics, 1998
- Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter studyAmerican Journal of Medical Genetics, 1996
- Seminars in Psychiatric GeneticsAmerican Journal of Psychiatry, 1996
- An international two–stage genome–wide search for schizophrenia susceptibility genesNature Genetics, 1995
- Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genesAmerican Journal of Medical Genetics, 1995