Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
Open Access
- 31 July 2009
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 325 (5940), 617-620
- https://doi.org/10.1126/science.1172747
Abstract
Maintaining Mutual Ignorance: Our gut is colonized by trillions of bacteria that do not activate the immune system because of careful compartmentalization. Such compartmentalization means that our immune system is “ignorant” of these microbes and thus it has been proposed that loss of compartmentalization might result in an immune response to the colonizing bacteria. Microorganisms are sensed by cells that express pattern recognition receptors, such as Toll-like receptors, which recognize patterns specific to those microbes. Slack et al. (p. 617 ) show that Toll-like receptor–dependent signaling is required to maintain compartmentalization of bacteria to the gut of mice. In the absence of Toll-dependent signaling, intestinal bacteria disseminated throughout the body and the mice mounted a high-titer antibody response against them. This antibody response was of great functional importance because, despite the loss of systemic ignorance to intestinal microbes, the mice were tolerant of the bacteria. Thus, in the absence of innate immunity, the adaptive immune system can compensate so that host and bacterial mutualism can be maintained.This publication has 25 references indexed in Scilit:
- Innate Immunity Mediated by MyD88 Signal Is Not Essential for Induction of Lipopolysaccharide-Specific B Cell Responses but Is Indispensable for Protection against Salmonella enterica serovar Typhimurium infectionThe Journal of Immunology, 2009
- Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interfaceProceedings of the National Academy of Sciences of the United States of America, 2008
- Pyogenic Bacterial Infections in Humans with MyD88 DeficiencyScience, 2008
- MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitisCellular Microbiology, 2008
- B cell–intrinsic TLR signals amplify but are not required for humoral immunityThe Journal of Experimental Medicine, 2007
- Recognition of microorganisms and activation of the immune responseNature, 2007
- Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor SignalingScience, 2006
- MyD88-Dependent Responses Involving Toll-Like Receptor 2 Are Important for Protection and Clearance ofLegionella pneumophilain a Mouse Model of Legionnaires' DiseaseInfection and Immunity, 2006
- Layers of mutualism with commensal bacteria protect us from intestinal inflammationGut, 2006
- Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal BacteriaScience, 2004