Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells
Open Access
- 3 March 2016
- journal article
- Published by American Society of Hematology in Blood
- Vol. 127 (9), 1138-1150
- https://doi.org/10.1182/blood-2015-06-649970
Abstract
Key Points SIRT6 is highly expressed in multiple myeloma cells and blocks expression of ERK-regulated genes. Targeting SIRT6 enzymatic activity sensitizes multiple myeloma cells to DNA-damaging agents.This publication has 54 references indexed in Scilit:
- Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancersNature Medicine, 2014
- Playing the End Game: DNA Double-Strand Break Repair Pathway ChoiceMolecular Cell, 2012
- Dysfunction of the TP53 tumor suppressor gene in lymphoid malignanciesBlood, 2012
- Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AXLeukemia, 2011
- Initial genome sequencing and analysis of multiple myelomaNature, 2011
- The DNA Damage Response: Making It Safe to Play with KnivesMolecular Cell, 2010
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation CarriersThe New England Journal of Medicine, 2009
- Suppression of the DNA damage response in acute myeloid leukemia versus myelodysplastic syndromeOncogene, 2009
- Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyNature, 2005
- Genetic instabilities in human cancersNature, 1998