Hyperintense Vessels on Acute Stroke Fluid-Attenuated Inversion Recovery Imaging
- 1 November 2012
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 43 (11), 2957-2961
- https://doi.org/10.1161/strokeaha.112.658906
Abstract
Background and Purpose—: Hyperintense vessels (HVs) have been observed in fluid-attenuated inversion recovery imaging of patients with acute ischemic stroke and been linked to slow flow in collateral arterial circulation. Given the potential importance of HV, we used a large, multicenter data set of patients with stroke to clarify which clinical and imaging factors play a role in HV. Methods—: We analyzed data of 516 patients from the previously published PRE-FLAIR study ( PRE dictive value of FLAIR and DWI for the identification of acute ischemic stroke patients ≤3 and ≤4.5 hours of symptom onset—a multicenter study) study. Patients were studied by MRI within 12 hours of symptom onset. HV were defined as hyperintensities in fluid-attenuated inversion recovery corresponding to the typical course of a blood vessel that was not considered the proximal, occluded main artery ipsilateral to the diffusion restriction. Presence of HV was rated by 2 observers and related to clinical and imaging findings. Results—: Presence of HV was identified in 240 of all 516 patients (47%). Patients with HV showed larger initial ischemic lesion volumes (median, 12.3 versus 4.9mL; P P P <0.001). HV detected vessel occlusion with a specificity of 0.86 (95% CI, 0.80–0.90) and sensitivity of 0.76 (95% CI, 0.69–0.83). Conclusions—: HVs are a common finding associated with proximal arterial occlusions and more severe strokes. HVs predict arterial occlusion with high diagnostic accuracy.This publication has 17 references indexed in Scilit:
- Hyperintense vessels on FLAIR: A useful non-invasive method for assessing intracerebral collateralsEuropean Journal of Radiology, 2011
- DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational studyThe Lancet Neurology, 2011
- Fluid-Attenuated Inversion Recovery Vascular Hyperintensities: An Important Imaging Marker for Cerebrovascular DiseaseAmerican Journal of Neuroradiology, 2010
- Prospective study on the mismatch concept in acute stroke patients within the first 24 h after symptom onset - 1000Plus studyBMC Neurology, 2009
- Distal hyperintense vessels on FLAIRNeurology, 2009
- Angiography Reveals That Fluid-Attenuated Inversion Recovery Vascular Hyperintensities Are Due to Slow Flow, Not ThrombusAmerican Journal of Neuroradiology, 2008
- Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trialThe Lancet Neurology, 2008
- Magnetization Transfer Imaging Shows Tissue Abnormalities in the Reversible PenumbraStroke, 2007
- Diagnostic and Prognostic Value of Early MR Imaging Vessel Signs in Hyperacute Stroke Patients Imaged <3 Hours and Treated with Recombinant Tissue Plasminogen Activator2005
- Fast FLAIR sequence for detecting major vascular abnormalities during the hyperacute phase of stroke: a comparison with MR angiographyNeuroradiology, 1999