Light-Induced Phase Shifts and Fos Expression in the Hamster Circadian System: The Effects of Anesthetics
- 1 October 1993
- journal article
- Published by SAGE Publications in Journal of Biological Rhythms
- Vol. 8 (3), 179-188
- https://doi.org/10.1177/074873049300800301
Abstract
In the present study, we examined the effect of administration of anesthetics on light-induced phase shifts of the circadian system. This information is of critical importance, because many studies of light input to the mammalian suprachiasmatic nucleus (SCN) have been performed on anesthetized animals. We found that light-induced phase shifts were blocked by all drugs used at anesthetic doses. We then determined the effect of two of these agents on light induction of Fos-like immunoreactivity in the SCN. We found that the administration of sodium pentobarbital prevented light induction of Fos expression in the SCN, whereas the administration of urethane did not. These results raise cautions about the use of anesthetized animals to answer questions about the photic regulation of neuronal activity in the SCN.Keywords
This publication has 34 references indexed in Scilit:
- Photic regulation of Fos‐like immunoreactivity in the suprachiasmatic nucleus of the mouseJournal of Comparative Neurology, 1992
- NMDA receptor antagonists block the effects of light on circadian behavior in the mouseBrain Research, 1991
- Photic induction of Fos protein in the suprachiasmatic nucleus is inhibited by the NMDA receptor antagonist MK-801Neuroscience Letters, 1991
- Do NMDA receptors mediate the effects of light on circadian behavior?Brain Research, 1990
- The phase-shifting effects of pentobarbital on the circadian rhythm of locomotor activity in the mouse: strain differencesBrain Research, 1988
- The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartateBritish Journal of Pharmacology, 1983
- Molecular mechanisms of general anaesthesiaNature, 1982
- Ventral lateral geniculate nucleus efferents to the rat suprachiasmatic nucleus exhibit avian pancreatic polypeptide‐like immunoreactivityJournal of Comparative Neurology, 1982
- Pentobarbitone pharmacology of mammalian central neurones grown in tissue culture.The Journal of Physiology, 1978
- Maintained discharge of rat suprachiasmatic neurons at different adaptation levelsNeuroscience Letters, 1978