Visualization of thalamic nuclei on high resolution, multi‐averaged T1 and T2 maps acquired at 1.5 T

Abstract

The ability to differentiate noninvasively between the primary nuclear divisions of the thalamus has immediate clinical applicability for surgical planning and guidance of functional stereotactic procedures. Comparison of prior qualitative magnetic resonance imaging (MRI) studies carried out at field strengths of 1.5 and 4 Tesla have revealed contrast within the thalamus that varies with field strength, suggesting possible differences in the inherent T₁ and T₂ relaxation times of the constituent nuclei. We investigate this hypothesis through acquisition of high‐resolution, multi‐averaged deep‐brain T₁ and T₂ maps of a healthy volunteer. Fourteen nuclei were identified using their center‐of‐mass coordinates (in Talairach space) and average T₁ and T₂ values obtained from regions of interest placed within each. Results from this analysis revealed significant differences in T₁ and T₂ between the nuclei with a T₁ range from 700 to 1,400 ms and a T₂ range from 89 to 122 ms, allowing visual discrimination between the major nuclei groups. Furthermore, the high‐resolution images showed distinct borders of T₁ and T₂ hypointensity surrounding each nucleus, revealing structure not reported previously. These results confirm our hypothesis and demonstrate the potential high‐resolution quantitative imaging for nucleus visualization and surgical planning. Hum Brain Mapp, 2005.