Post-Treatment Hemodynamics of a Basilar Aneurysm and Bifurcation
- 16 July 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Annals of Biomedical Engineering
- Vol. 36 (9), 1531-1546
- https://doi.org/10.1007/s10439-008-9535-7
Abstract
To investigate whether or not a successful aneurysm treatment procedure can subject a parent artery to harmful hemodynamic stresses, computational fluid dynamics simulations are performed on a patient-specific basilar aneurysm and bifurcation before and after a virtual endovascular treatment. Prior to treatment, the aneurysm at systole is filled with a periodic train of vortex tubes, which form at the aneurysm neck and advect upwards into the dome. Following the treatment procedure however, the motion of the vortex train is inhibited by the aneurysm filling material, which confines the vortex tubes to the region beneath the aneurysm neck. Analysis of the post-treatment flow field indicates that the impingement of the basilar artery flow upon the treated aneurysm neck and the close proximity of a vortex tube to the parent artery wall increase the maximum wall shear stresses to values approximately equal to 50 Pa at systole. Calculation of the time-averaged wall shear stresses indicates that there is a 1.4 × 10−7 m2 area on the parent artery exposed to wall shear stresses greater than 37.9 Pa, a value shown by Fry [Circ. Res. 22(2):165–197, 1968] to cause severe damage to the endothelial cells that line the artery wall. The results of this study demonstrate that it is possible for a treatment procedure, which successfully isolates the aneurysm from the circulation and leaves no aneurysm neck remnant, to elevate the hemodynamic stresses to levels that are injurious to the artery wall.Keywords
This publication has 58 references indexed in Scilit:
- Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm InitiationStroke, 2007
- Three-dimensional instabilities and transition of steady and pulsatile axisymmetric stenotic flowsJournal of Fluid Mechanics, 2005
- Use of Quantitative Magnetic Resonance Angiography to Stratify Stroke Risk in Symptomatic Vertebrobasilar DiseaseStroke, 2005
- Increased cerebral blood flow in preeclampsia with magnetic resonance imagingAmerican Journal of Obstetrics and Gynecology, 2004
- Matrix and Bioabsorbable Polymeric Coils Accelerate Healing of Intracranial AneurysmsStroke, 2003
- Risk of Aneurysm Recurrence in Patients With Clipped Cerebral AneurysmsStroke, 2001
- Topology of fine-scale motions in turbulent channel flowJournal of Fluid Mechanics, 1996
- Remodeling of the Radial Artery in Response to a Chronic Increase in Shear StressHypertension, 1996
- Unsteady Entrance Flow Development in a Straight TubeJournal of Biomechanical Engineering, 1994
- Lipid Transport Aspects of AtherogenesisJournal of Biomechanical Engineering, 1993