Extrapolation from ten sections can make CT-based quantification of lung aeration more practicable
- 6 August 2010
- journal article
- Published by Springer Science and Business Media LLC in Intensive Care Medicine
- Vol. 36 (11), 1836-1844
- https://doi.org/10.1007/s00134-010-2014-2
Abstract
Purpose Clinical applications of quantitative computed tomography (qCT) in patients with pulmonary opacifications are hindered by the radiation exposure and by the arduous manual image processing. We hypothesized that extrapolation from only ten thoracic CT sections will provide reliable information on the aeration of the entire lung. Methods CTs of 72 patients with normal and 85 patients with opacified lungs were studied retrospectively. Volumes and masses of the lung and its differently aerated compartments were obtained from all CT sections. Then only the most cranial and caudal sections and a further eight evenly spaced sections between them were selected. The results from these ten sections were extrapolated to the entire lung. The agreement between both methods was assessed with Bland–Altman plots. Results Median (range) total lung volume and mass were 3,738 (1,311–6,768) ml and 957 (545–3,019) g, the corresponding bias (limits of agreement) were 26 (−42 to 95) ml and 8 (−21 to 38) g, respectively. The median volumes (range) of differently aerated compartments (percentage of total lung volume) were 1 (0–54)% for the nonaerated, 5 (1–44)% for the poorly aerated, 85 (28–98)% for the normally aerated, and 4 (0–48)% for the hyperaerated subvolume. The agreement between the extrapolated results and those from all CT sections was excellent. All bias values were below 1% of the total lung volume or mass, the limits of agreement never exceeded ±2%. Conclusion The extrapolation method can reduce radiation exposure and shorten the time required for qCT analysis of lung aeration.Keywords
This publication has 44 references indexed in Scilit:
- Physiological and Computed Tomographic Predictors of Outcome from Lung Volume Reduction SurgeryAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Bildqualität aufaddierter Schichten bei MSCT-Untersuchungen des Thorax: Bildnachverarbeitung versus DirektrekonstruktionRöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 2007
- Analysis of the nonaerated lung volume in combinations of single computed tomography slices – is extrapolation to the entire lung feasible?Critical Care, 2007
- Radiological Imaging in Acute Lung Injury and Acute Respiratory Distress SyndromeSeminars in Respiratory and Critical Care Medicine, 2006
- Lung Recruitment in Patients with the Acute Respiratory Distress SyndromeNew England Journal of Medicine, 2006
- Measurement of pulmonary edema in patients with acute respiratory distress syndrome*Critical Care Medicine, 2005
- Computed tomography assessment of lung structure and function in pulmonary emphysemaPublished by European Respiratory Society (ERS) ,2004
- Repeatability of Lung Density Measurements with Low-Dose Computed Tomography in Subjects with α-1-Antitrypsin Deficiency–Associated EmphysemaInvestigative Radiology, 2001
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986
- Functional Residual Capacity, Thoracoabdominal Dimensions, and Central Blood Volume during General Anesthesia with Muscle Paralysis and Mechanical VentilationAnesthesiology, 1985