The Vascular Effects of Infection in Pediatric Stroke (VIPS) Study
Open Access
- 25 May 2011
- journal article
- research article
- Published by SAGE Publications in Journal of Child Neurology
- Vol. 26 (9), 1101-1110
- https://doi.org/10.1177/0883073811408089
Abstract
Understanding the vascular injury pathway is crucial to developing rational strategies for secondary stroke prevention in children. The multicenter Vascular Effects of Infection in Pediatric Stroke (VIPS) cohort study will test the hypotheses that (1) infection can lead to childhood arterial ischemic stroke by causing vascular injury and (2) resultant arteriopathy and inflammatory markers predict recurrent stroke. The authors are prospectively enrolling 480 children (aged 1 month through 18 years) with arterial ischemic stroke and collecting extensive infectious histories, blood and serum samples (and cerebrospinal fluid, when clinically obtained), and standardized brain and cerebrovascular imaging studies. Laboratory assays include serologies (acute and convalescent) and molecular assays for herpesviruses and levels of inflammatory markers. Participants are followed prospectively for recurrent ischemic events (minimum of 1 year). The analyses will measure association between markers of infection and cerebral arteriopathy and will assess whether cerebral arteriopathy and inflammatory markers predict recurrent stroke.Keywords
This publication has 77 references indexed in Scilit:
- Imaging Data Reveal a Higher Pediatric Stroke Incidence Than Prior US EstimatesStroke, 2009
- Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18European Heart Journal, 2008
- Serum Myeloperoxidase Levels Are Associated With the Future Risk of Coronary Artery Disease in Apparently Healthy Individuals: The EPIC-Norfolk Prospective Population StudyJournal of the American College of Cardiology, 2007
- Myeloperoxidase predicts risk of vasculopathic events in hemizgygous males with Fabry diseaseNeurology, 2006
- C-Reactive Protein Predicts Further Ischemic Events in First-Ever Transient Ischemic Attack or Stroke Patients With Intracranial Large-Artery Occlusive DiseaseStroke, 2003
- Infection and the Risk of Spontaneous Cervical Artery DissectionStroke, 2003
- Chickenpox and Stroke in ChildhoodStroke, 2001
- Acute-Phase Proteins and Other Systemic Responses to InflammationThe New England Journal of Medicine, 1999
- Recent Infection as a Risk Factor for Cerebrovascular IschemiaStroke, 1995
- Subarachnoid hemorrhage and granulomatous angiitis of the basilar artery: demonstration of the varicella-zoster-virus in the basilar artery lesions.Stroke, 1986