Total Synthesis of (±)-Aspidophylline A
- 18 May 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 133 (23), 8877-8879
- https://doi.org/10.1021/ja203227q
Abstract
We report the total synthesis of (+/-)-aspidophylline A, one of many complex furoindoline-containing alkaloids that has not been synthesized previously. Our route features a number of key transformations, including a Heck cyclization to assemble the [3.3.1]-bicyclic scaffold as well as a late-stage interrupted Fischer indolization to install the furoindoline and construct the natural product's pentacyclic framework.Keywords
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