Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection.
Open Access
- 1 October 1987
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 166 (4), 1132-1137
- https://doi.org/10.1084/jem.166.4.1132
Abstract
A sensitive radioimmunoassay was used for monitoring serum levels of endogenous cachectin/tumor necrosis factor alpha (TNF) in 10 renal transplant recipients. Acute allograft rejections were associated with marked elevations of circulating TNF. The peak levels of TNF (median 140 pg/ml) were in the same concentration range as previously reported in parasitic infections. The results show that the release of TNF into circulation is an early event in renal allograft rejection and that raised levels of TNF in man can also be induced by noninfectious stimuli.This publication has 20 references indexed in Scilit:
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