Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
Top Cited Papers
Open Access
- 25 April 2013
- journal article
- research article
- Published by Elsevier BV in Neuron
- Vol. 78 (4), 631-643
- https://doi.org/10.1016/j.neuron.2013.04.014
Abstract
• CD33 is expressed in microglia and exhibits increased expression in AD • Numbers of CD33-immunoreactive microglia positively correlate with Aβ plaque burden • CD33 inhibits microglial uptake of Aβ42 • CD33 inactivation reduces insoluble Aβ42 levels in the APPSwe/PS1ΔE9 mouse brainKeywords
This publication has 57 references indexed in Scilit:
- Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's DiseaseThe American Journal of Pathology, 2011
- Targeting Siglecs—A novel pharmacological strategy for immuno- and glycotherapyBiochemical Pharmacology, 2011
- Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's diseaseNature Genetics, 2011
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's diseaseNature Genetics, 2011
- Genome-wide Analysis of Genetic Loci Associated With Alzheimer DiseaseJAMA, 2010
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseNature Genetics, 2009
- Siglecs as targets for therapy in immune-cell-mediated diseaseTrends in Pharmacological Sciences, 2009
- Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOEAmerican Journal of Human Genetics, 2008
- Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and DifferentiationNeuron, 2008
- ApoE Promotes the Proteolytic Degradation of AβNeuron, 2008