Colon-specific delivery and enhanced colonic absorption of [Asu1,7]-eel calcitonin using chitosan capsules containing various additives in rats
- 1 January 2006
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Drug Targeting
- Vol. 14 (3), 165-172
- https://doi.org/10.1080/10611860600648494
Abstract
The objective of this study was to estimate the colon-specific delivery of [Asu1,7]-eel calcitonin (ECT) using chitosan capsules in rats. The intestinal absorption of ECT was evaluated by measuring the plasma calcium levels after oral administration of the chitosan capsules containing ECT and different combinations of additives. The same combinations were investigated by an in situ absorption experiment prior to in vivo administration of capsules. A marked decrease in plasma calcium levels was observed following the oral administration of chitosan capsules containing ECT, S-nitroso-N-acetyl-dl-penicillamine (SNAP), sodium glycocholate, bacitracin and aprotinin (pharmacological availability (PA)% = 6.344%), as compared with capsules containing only ECT (PA% = 0.551%) or capsules containing ECT with SNAP only (PA% = 1.651%). The hypocalcemic effect started 6–8 h after oral administration of capsules and sustained for 24 h. These findings suggest that colon-specific delivery of ECT can be achieved using chitosan capsules and these additives may be useful for improving the colonic absorption of ECT in rats.Keywords
This publication has 36 references indexed in Scilit:
- Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-β-cyclodextrinsInternational Journal of Pharmaceutics, 2003
- Enhanced Permeability of Insulin across the Rat Intestinal Membrane by Various Absorption Enhancers: Their Intestinal Mucosal Toxicity and Absorption-enhancing Mechanism of n-Lauryl-β-D-maltopyranosideJournal of Pharmacy and Pharmacology, 1999
- Use of Azo Polymers for Colon-Specific Drug DeliveryJournal of Pharmaceutical Sciences, 1997
- Effects of Protease Inhibitors on the Absorption of Phenol Red and Fluorescein Isothiocyanate Dextrans from the Rat IntestineJournal of Pharmaceutical Sciences, 1996
- Absorption Characteristics of Chemically Modified‐Insulin Derivatives with Various Fatty Acids in the Small and Large IntestineJournal of Pharmaceutical Sciences, 1995
- Hydrocolloids and gels of chitosan as drug carriersInternational Journal of Pharmaceutics, 1993
- The colon as a site for drug deliveryJournal of Controlled Release, 1992
- A New Approach to the Oral Administration of Insulin and Other Peptide DrugsScience, 1986
- Effect of surfactants on the nasal absorption of insulin in ratsInternational Journal of Pharmaceutics, 1981
- Bacitracin: An inhibitor of the insulin degrading activity of glutathione-insulin transhydrogenaseBiochemical and Biophysical Research Communications, 1981