Distinct Effects of T-bet in T H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells
Top Cited Papers
- 11 January 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 295 (5553), 338-342
- https://doi.org/10.1126/science.1065543
Abstract
T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (T H ) lymphocytes in part by activating the hallmark T H 1 cytokine, interferon-γ (IFN-γ). IFN-γ is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-γ production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-γ, is controlled by distinct transcriptional mechanisms within the T cell lineage.Keywords
This publication has 28 references indexed in Scilit:
- Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 MutationScience, 2001
- Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndromeNature Genetics, 1997
- CELLULAR RESPONSES TO INTERFERON-γAnnual Review of Immunology, 1997
- THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor SignalingAnnual Review of Immunology, 1997
- Mutations in human cause limb and cardiac malformation in Holt-Oram syndromeNature Genetics, 1997
- Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral DiseaseCell, 1996
- Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling PathwayCell, 1996
- The Regulation of Immunity to Leishmania MajorAnnual Review of Immunology, 1995
- Immune Response in Mice that Lack the Interferon-γ ReceptorScience, 1993
- Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ GenesScience, 1993