Gastric Hydrochloric Acid Secretory Response to Orally Administered Betazole Hydrochloride

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Abstract
THE extensive clinical investigation of betazole hydrochloride (3-[beta-aminoethyl] pyrazole) by Kirsner and Ford,1 in addition to previous reports,2 , 3 has shown that this compound administered subcutaneously is a more potent and less toxic gastric stimulant than histamine. The present study, consisting of a comparison of the gastric hydrochloric acid secretory response to orally and subcutaneously administered betazole hydrochloride, was undertaken to find a more potent gastric stimulant than caffeine for the detection of achlorhydria by tubeless gastric analysis.4 Betazole hydrochloride first synthesized by Lee and Jones5 is an isomer of histamine with a pyrazole in the ring instead of an imidazole . . .