Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
- 1 January 1995
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 373 (6510), 123-126
- https://doi.org/10.1038/373123a0
Abstract
Treatment of infected patients with ABT-538, an inhibitor of the protease of human immunodeficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.Keywords
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