Systemic Reactions to Allergen Immunotherapy: A Review of the Literature
- 1 January 2003
- journal article
- review article
- Published by Informa UK Limited in Immunopharmacology and Immunotoxicology
- Vol. 25 (1), 1-11
- https://doi.org/10.1081/iph-120018279
Abstract
Since its introduction the safety of specific immunotherapy (SIT) was assessed by many well-designed studies. SIT is accepted as an effective treatment of allergic diseases despite the occurrence of side-effects, among which systemic reactions (SRs) are the most dangerous. The reported frequency of SRs after SIT varies among the studies and several factors influence it. Asthma is a particular risk factor for systemic side-effects. Furthermore, SRs occur more often in patients with high allergen sensitivity as determined by skin testing or RAST. Making dosage errors is also considered to be a high risk. It is reported that reactions are more common during rush and clustered induction treatment, whereas a significantly lower incidence of SRs occurred with the use of standardized modified allergen vaccines than with aqueous extracts. On the basis of valuable guidelines, precautions to minimize the risk of SRs from SIT were recommended. Injections should be given or supervised by doctors well-trained in this form of treatment in a clinic where there is the immediate availability of a resuscitative equipment. Consideration should be given to evaluate the patient's conditions and to monitor subjects for a minimum of 30 minutes after the injections. Therefore, if appropriately done, the risk of SIT is negligible.Keywords
This publication has 38 references indexed in Scilit:
- A prospective safety-monitoring study of immunotherapy in mite-allergy patients with mass-units-standardized extractAllergy, 1997
- Immediate adverse reactions to immunotherapy in allergyAllergy, 1992
- Specific immunotherapy in asthmaJournal of Allergy and Clinical Immunology, 1990
- Immunotherapy with a standardized Dermatophagoides pteronyssinus extractJournal of Allergy and Clinical Immunology, 1989
- Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids I. Rush immunotherapy with allergoids and standardized orchard grass-pollen extractJournal of Allergy and Clinical Immunology, 1987
- Diagnosis and Immunotherapy of Mould AllergyAllergy, 1986
- Modified forms of allergen immunotherapyJournal of Allergy and Clinical Immunology, 1985
- Studies on allergoids from naturally occurring allergens IV. Efficacy and safety of long-term allergoid treatment of ragweed hay feverJournal of Allergy and Clinical Immunology, 1981
- Rush venom immunotherapy program for honeybee sting sensitivityJournal of Allergy and Clinical Immunology, 1979
- A Controlled Trial of Immunotherapy in Insect HypersensitivityNew England Journal of Medicine, 1978