Accumulation of p62 is associated with poor prognosis in patients with triple-negative breast cancer
Open Access
- 1 July 2013
- journal article
- Published by Taylor & Francis Ltd in OncoTargets and Therapy
- Vol. 6, 883-888
- https://doi.org/10.2147/ott.s46222
Abstract
Background: Triple-negative breast cancer (TNBC) is associated with poor prognosis. There is an urgent need for elucidation of novel targets for TNBC therapy and to improve the prognosis of patients. The aim of this study was to evaluate the prognostic value of p62 expression in TNBC. Methods and results: Expression of p62 in tissue microarray was evaluated by immunohistochemistry in 163 patients with TNBC. The prognostic value of p62 expression was assessed by a Cox regression model adjusted for clinical characteristics. Overexpression of p62 was observed in 51 (31.3%) of 163 TNBC, and significantly correlated with advanced stage and a higher proportion of positive lymph nodes and lymphovascular invasion. A significant correlation was found between p62 expression and disease-free survival and overall survival. Accordingly, the 10-year distant metastasis-free survival for p62-overexpression and p62-underexpression patients were 58.9% and 92.5%, respectively (PP=0.017), but not for overall survival (P=0.845) in all patients. Conclusion: Our results suggest that overexpression of p62 in TNBC is associated with a higher risk of distant metastases. This finding could open new avenues for the development of novel therapy strategies for TNBC.Keywords
This publication has 24 references indexed in Scilit:
- p62: a versatile multitasker takes on cancerTrends in Biochemical Sciences, 2012
- Autophagy-deficient mice develop multiple liver tumorsGenes & Development, 2011
- Autophagy Suppresses Tumorigenesis through Elimination of p62Cell, 2009
- Role of autophagy in cancerNature Reviews Cancer, 2007
- Triple-Negative Breast Cancer: Clinical Features and Patterns of RecurrenceClinical Cancer Research, 2007
- Use of immunohistochemical markers can refine prognosis in triple negative breast cancerBMC Cancer, 2007
- Autophagy suppresses tumor progression by limiting chromosomal instabilityGenes & Development, 2007
- Descriptive analysis of estrogen receptor (ER)‐negative, progesterone receptor (PR)‐negative, and HER2‐negative invasive breast cancer, the so‐called triple‐negative phenotypeCancer, 2007
- The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer SubtypesClinical Cancer Research, 2007
- Phenotypic evaluation of the basal-like subtype of invasive breast carcinomaLaboratory Investigation, 2005