Soursop extract used to show its effects on the xanthine oxidase activity by inhibition its ability to produce uric acid, the principal reason for the gout and other inflammatory diseases. The fractionation results shows that the major fraction of phenolic compounds is cumarin separated by revise phase high performance chromatography (HPLC) which shows by in vitro test a considerable inhibition of the xanthine oxidase activity equal to 72.15 ± 0.70 compared with positive control (Allopurinol) (P < 0.05) which lead to reduce production of uric acid. The atomic absorption analysis (AA) of trace elements (Fe, Zn, Mg, P) shows the presence of such metals in soursop sample in an amount nessacery for many metabolic processes in human body. In conclusion the cumarin can used as treatment for gout instead of allpurinol because of its side effect. Further histopathological studies need to explore such study to show the effect of cumarin and trace elements on liver and other organs in animal samples.