Cyclic Stretch, Reactive Oxygen Species, and Vascular Remodeling
- 1 July 2009
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 11 (7), 1651-1667
- https://doi.org/10.1089/ars.2008.2390
Abstract
Blood vessels respond to changes in mechanical load from circulating blood in the form of shear stress and mechanical strain as the result of heart propulsions by changes in intracellular signaling leading to changes in vascular tone, production of vasoactive molecules, and changes in vascular permeability, gene regulation, and vascular remodeling. In addition to hemodynamic forces, microvasculature in the lung is also exposed to stretch resulting from respiratory cycles during autonomous breathing or mechanical ventilation. Among various cell signaling pathways induced by mechanical forces and reported to date, a role of reactive oxygen species (ROS) produced by vascular cells receives increasing attention. ROS play an essential role in signal transduction and physiologic regulation of vascular function. However, in the settings of chronic hypertension, inflammation, or acute injury, ROS may trigger signaling events that further exacerbate smooth muscle hypercontractility and vascular remodeling associated with hypertension and endothelial barrier dysfunction associated with acute lung injury and pulmonary edema. These conditions are also characterized by altered patterns of mechanical stimulation experienced by vasculature. This review will discuss signaling pathways regulated by ROS and mechanical stretch in the pulmonary and systemic vasculature and will summarize functional interactions between cyclic stretch- and ROS-induced signaling in mechanochemical regulation of vascular structure and function. Antioxid. Redox Signal. 11, 1651–1667.Keywords
This publication has 188 references indexed in Scilit:
- EGFR-Activated Signaling and Actin Remodeling Regulate Cyclic Stretch–Induced NRF2-ARE ActivationAmerican Journal of Respiratory Cell and Molecular Biology, 2007
- Differential Regulation of Pulmonary Endothelial Monolayer Integrity by Varying Degrees of Cyclic StretchThe American Journal of Pathology, 2006
- VEGF receptor signalling ? in control of vascular functionNature Reviews Molecular Cell Biology, 2006
- Reactive oxygen species in vascular biology: implications in hypertensionHistochemistry and Cell Biology, 2004
- p38 MAP Kinase—a molecular switch between VEGF‐induced angiogenesis and vascular hyperpermeabilityThe FASEB Journal, 2002
- Signaling Pathways of Mechanotransduction in Arteriolar Endothelium and Smooth Muscle Cells in HypertensionMicrocirculation, 2002
- Reactive Oxygen Species in Mechanical Stress-Induced Cardiac HypertrophyBiochemical and Biophysical Research Communications, 2001
- Differential Regulation of Alternatively Spliced Endothelial Cell Myosin Light Chain Kinase Isoforms by p60SrcJournal of Biological Chemistry, 2001
- Endothelin-1 Induces NAD(P)H Oxidase in Human Endothelial CellsBiochemical and Biophysical Research Communications, 2000
- Involvement of rho p21 in Cyclic Strain-Induced Tyrosine Phosphorylation of Focal Adhesion Kinase (pp125FAK), Morphological Changes and Migration of Endothelial CellsBiochemical and Biophysical Research Communications, 1996