Animal models of head trauma
Top Cited Papers
- 1 July 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in NeuroRX
- Vol. 2 (3), 410-422
- https://doi.org/10.1602/neurorx.2.3.410
Abstract
Animal models of traumatic brain injury (TBI) are used to elucidate primary and secondary sequelae underlying human head injury in an effort to identify potential neuroprotective therapies for developing and adult brains. The choice of experimental model depends upon both the research goal and underlying objectives. The intrinsic ability to study injury-induced changes in behavior, physiology, metabolism, the blood/tissue interface, the blood brain barrier, and/or inflammatory- and immune-mediated responses, makes in vivo TBI models essential for neurotrauma research. Whereas human TBI is a highly complex multifactorial disorder, animal trauma models tend to replicate only single factors involved in the pathobiology of head injury using genetically well-defined inbred animals of a single sex. Although such an experimental approach is helpful to delineate key injury mechanisms, the simplicity and hence inability of animal models to reflect the complexity of clinical head injury may underlie the discrepancy between preclinical and clinical trials of neuroprotective therapeutics. Thus, a search continues for new animal models, which would more closely mimic the highly heterogeneous nature of human TBI, and address key factors in treatment optimization.Keywords
This publication has 144 references indexed in Scilit:
- The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in ratsNeurobiology of Disease, 2004
- Attenuation of the Electrophysiological Function of the Corpus Callosum after Fluid Percussion Injury in the RatJournal of Neurotrauma, 2002
- A New Model for Diffuse Brain Injury by Rotational Acceleration: I. Model, Gross Appearance, and AstrocytosisJournal of Neurotrauma, 2001
- Continuous Infusion of Cyclosporin A Postinjury Significantly Ameliorates Cortical Damage Following Traumatic Brain InjuryExperimental Neurology, 2000
- A new experimental model of contusion in the ratJournal of Neurosurgery, 1996
- β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injuryNeuroscience Letters, 1993
- Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injuryJournal of Neurosurgery, 1992
- The Effect of Hypoxia on Traumatic Head Injury in Rats: Alterations in Neurologic Function, Brain Edema, and Cerebral Blood FlowJournal of Cerebral Blood Flow & Metabolism, 1987
- Axonal regeneration after crush injury of rat central nervous system fibres innervating peripheral nerve graftsJournal of Neurocytology, 1985
- Experimental head injury in the ratJournal of Neurosurgery, 1977