Autofluorescent Imaging in Patients With Peritoneal Carcinomatosis
- 9 July 2013
- journal article
- Published by SAGE Publications in Surgical Innovation
- Vol. 21 (2), 187-193
- https://doi.org/10.1177/1553350613495114
Abstract
Background and objectives. Autofluorescence imaging (AFI) is mainly used to detect (pre)cancerous colorectal and pulmonal lesions. This is the first report establishing the feasibility of AFI in patients with peritoneal carcinomatosis (PC). Methods. This is a prospective analysis of 10 patients undergoing conventional white-light laparoscopy (WL) and AFI for PC of different gastrointestinal tumors and 1 ovarian cancer. Before taking biopsies, suspicious peritoneal lesions were first detected by WL and then investigated by AFI. The intraoperative findings were photographed and then correlated with histological results. Results. Conventional WL and AFI evaluation was successful in all patients. A total of 38 biopsies were taken. The neoplasm detection rate under WL was 66% and increased to 86% when using AFI. The positive tumor detection rate was slightly higher in low AF lesions (83 vs 88%) and higher in tumor nodules (94%) than in flat peritoneal lesions (75%). For tumor nodules, the sensitivity was 94%, and the specificity was 100%. For flat lesions, the sensitivity was 75% and specificity 50%. Conclusions. We demonstrate the feasibility and effectiveness of AFI in patients with PC.Keywords
This publication has 30 references indexed in Scilit:
- Advances in endoscopic visualization of colorectal polypsColorectal Disease, 2011
- Evaluation of autofluorescence colonoscopy for diagnosis of superficial colorectal neoplastic lesionsInternational Journal of Colorectal Disease, 2010
- Secondary Tumors and Tumorlike Lesions of the Peritoneal Cavity: Imaging Features with Pathologic CorrelationRadioGraphics, 2009
- Complete Cytoreductive Surgery Plus Intraperitoneal Chemohyperthermia With Oxaliplatin for Peritoneal Carcinomatosis of Colorectal OriginJournal of Clinical Oncology, 2009
- Detection of peritoneal endometriotic lesions by autofluorescence laparoscopyAmerican Journal of Obstetrics and Gynecology, 2006
- Endoscopic video-autofluorescence imaging followed by narrow band imaging for detecting early neoplasia in Barrett's esophagusGastrointestinal Endoscopy, 2006
- Autofluorescence Imaging and Narrow-Band Imaging for the Detection of Early Neoplasia in Patients with Barrett’s EsophagusEndoscopy, 2006
- Autofluorescence excitation-emission matrices for diagnosis of colonic cancerWorld Journal of Gastroenterology, 2005
- Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy for the Management of Peritoneal Carcinomatosis From Colorectal Cancer: A Multi-Institutional StudyJournal of Clinical Oncology, 2004
- In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indicesLasers in Surgery and Medicine, 1995