This review's primary objective is to identify research examining the impact of rest breaks uponaccident risk in industrial settings. In the absence of much directly relevant research, the focus isbroadened to consider the impact of rest breaks upon performance and fatige, as well asepidemioogical evidence, in both transport and non-transport settings. Relevant studies are identifiedfrom a range of electronic sources. In general, regular rest breaks can be an effective means ofmaintaining performance, managing fatigue and controlling the accumulation of risk over prolongedtask perfonmance. While two-hourly breaks are common in many industrial settings, the scheduling ofadditional micro-breaks can be beneficial under at least some circumstances. While some evidencesupports allowing workers to take rest breaks that coincide with periods of heightened fatigue,workers sometims fail to take adequate breaks when they are needed. There is little hard evidenceconcerning the optimun length of rest breaks (other than for heavy physical work), or to support thecontention that increased rest-breaks can off-set the negative inpact of extending shift durations, or tosuggest that rest breaks counteract the neptive impacts of circadian variations in alertness, unless theyinvolve taking a nap or caffeine. The scarcity of epidemiological evidence in this area highlights theneed for more research.