Assessment of renal allograft fibrosis by acoustic radiation force impulse quantification - a pilot study
Open Access
- 2 September 2010
- journal article
- Published by Frontiers Media SA in Transplant International
- Vol. 24 (1), 100-105
- https://doi.org/10.1111/j.1432-2277.2010.01165.x
Abstract
Chronic allograft nephropathy characterized by interstitial fibrosis and tubular atrophy is a major cause of renal transplant failure. Acoustic radiation force impulse (ARFI) quantification is a promising noninvasive method for assessing tissue stiffness. We evaluated if the method could reveal renal transplant fibrosis. In a prospective study, 30 adult renal transplant recipients were included. ARFI quantification, given as shear wave velocity (SWV), of the renal cortex was performed by two observers. SWV was compared to grade of fibrosis (0–3) in biopsies. The median SWV was 2.8 m/s (range: 1.6–3.6), 2.6 m/s (range: 1.8–3.5) and 2.5 m/s (range: 1.6–3) for grade 0 (n = 12), 1 (n = 10) and grades 2/3 (n = 8) fibrosis respectively. SWV did not differ significantly in transplants without and with fibrosis (grade 0 vs. grade 1, P = 0.53 and grade 0 vs. grades 2/3, P = 0.11). The mean intraobserver coefficient of variation was 22% for observer 1 and 24% for observer 2. Interobserver agreement, expressed as intraclass correlation coefficient was 0.31 (95% CI: −0.03 to 0.60). This study does not support the use of ARFI quantification to assess low‐grade fibrosis in renal transplants. ARFI quantification in its present stage of development has also high intra‐ and interobserver variation in renal transplants.Keywords
This publication has 15 references indexed in Scilit:
- Noninvasive evaluation of renal allograft fibrosis by transient elastography - a pilot studyTransplant International, 2010
- Functional and morphologic evaluation of kidney proximal tubuli and correlation with renal allograft prognosisTransplant International, 2009
- Comparison of liver stiffness, fibrotest and liver biopsy for assessment of liver fibrosis in kidney-transplant patients with chronic viral hepatitisTransplant International, 2009
- Renal TransplantsUltrasound Quarterly, 2008
- Quantifying Hepatic Shear Modulus In Vivo Using Acoustic Radiation ForceJapanese Journal of Clinical Oncology, 2008
- Chronic Allograft Nephropathy: What Have We Learned From Protocol Biopsies?Transplantation, 2008
- Imaging and Estimation of Tissue Elasticity by UltrasoundUltrasound Quarterly, 2007
- Feasibility of applying ultrasound strain imaging to detect renal transplant chronic allograft nephropathyKidney International, 2004
- Measurements of cortical interstitium in biopsies from human kidney grafts: how representative and how reproducible?Nephrology Dialysis Transplantation, 2002
- The Banff 97 working classification of renal allograft pathologyKidney International, 1999