Distribution of hematoporphyrin derivative in canine glioma following intraneoplastic and intraperitoneal injection
- 1 September 1986
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 65 (3), 364-369
- https://doi.org/10.3171/jns.1986.65.3.0364
Abstract
Hematoporphyrin derivative (HPD) is a photosensitizing agent that has been used to locate and kill tumors. The distribution of tritiated (3H)-HPD was studied in a transplantable canine glioma model following intraperitoneal or direct intraneoplastic injection. Compared to intraperitoneal administration of 3H-HPD, direct injection resulted in levels that were more than 2.5 times higher in tumor tissue and approximately 10 times lower in skin. Dose-corrected analysis of the data indicated that outside the central nervous system (CNS) the distribution of 3H-HPD is dose-related, regardless of route of injection. Within the CNS, direct injection leads to more efficient uptake of 3H-HPD, especially at the tumor periphery. Fluorescence microscopy confirmed the selective biodistribution of HPD fluorescence within the cytoplasm of tumor cells.Keywords
This publication has 16 references indexed in Scilit:
- Distribution, retention, and phototoxicity of hematoporphyrin derivative in a rat gliomaJournal of Neurosurgery, 1986
- Quantitation of Hematoporphyrin Derivative in Human Gliomas, Experimental Central Nervous System Tumors, and Normal TissuesNeurosurgery, 1983
- Quantitation of hematoporphyrin derivative in human gliomas, experimental central nervous system tumors, and normal tissuesNeurosurgery, 1983
- Transplantable Canine Glioma Model for Use in Experimental Neuro-oncologyNeurosurgery, 1982
- Photoradiation Therapy in the Treatment of Malignant Brain TumorsNeurosurgery, 1981
- Glioblastoma multiformeThe American Journal of the Medical Sciences, 1980
- Intraneoplastic injection of methotrexate for experimental brain-tumor chemotherapyJournal of Neurosurgery, 1977
- Chemotherapeutic implications of growth fraction and cell cycle time in glioblastomasJournal of Neurosurgery, 1975
- Cell kinetics of human gliomasJournal of Neurosurgery, 1972
- Untersuchungen über die Rolle der Porphyrine bei geschwulstkranken Menschen und TierenZeitschrift für Krebsforschung und Klinische Onkologie, 1942