Pediatric Thyroid Cancer
- 1 August 2017
- journal article
- review article
- Published by Elsevier BV in Advances in Pediatrics
- Vol. 64 (1), 171-190
- https://doi.org/10.1016/j.yapd.2017.03.007
Abstract
A review was undertaken of the clinical, gross, and microscopic features of thyroid carcinoma in all patients younger than 21 years of age seen at North Carolina Memorial Hospital from 1952 to 1987 (N = 32). These patients had papillary carcinoma, well-differentiated follicular carcinoma with Hürthle cell change, medullary carcinoma, and an unclassifiable aggressive malignancy. In spite of the presence of lymph node metastases at diagnosis in more half the patients with papillary carcinoma, the prognosis of pediatric papillary thyroid carcinoma appears to be excellent with treatment by surgical debulking and hormonal thyroid suppression. Flow cytometric study of 26 cases showed tumor aneuploidy in 8 of 21 papillary carcinomas and 2 of 3 follicular carcinomas. Aneuploidy did not, however, correlate with clinical outcome in this group of pediatric patients, who were followed for 1 to 29 years. Analysis of multiple tissue blocks of tumor does appear to increase the probability of identifying aneuploid popula...Keywords
This publication has 50 references indexed in Scilit:
- Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid CarcinomaJAMA Oncology, 2016
- Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid CancerThyroid®, 2015
- Molecular genetics and diagnosis of thyroid cancerNature Reviews Endocrinology, 2011
- Thyroid Nodules and Cancer in Children with PTEN Hamartoma Tumor SyndromeJournal of Clinical Endocrinology & Metabolism, 2011
- Pediatric Thyroid Carcinoma: Incidence and Outcomes in 1753 PatientsJournal of Surgical Research, 2009
- Increasing incidence of differentiated thyroid cancer in the United States, 1988–2005Cancer, 2009
- Rising Thyroid Cancer Incidence in the United States by Demographic and Tumor Characteristics, 1980-2005Cancer Epidemiology, Biomarkers & Prevention, 2009
- Mechanisms of Disease: molecular genetics of childhood thyroid cancersNature Clinical Practice Endocrinology & Metabolism, 2007
- BRAF Mutations are Uncommon in Papillary Thyroid Cancer of Young PatientsThyroid®, 2005
- Childhood Thyroid Diseases around Chernobyl Evaluated by Ultrasound Examination and Fine Needle Aspiration CytologyThyroid®, 1995