Mitochondrial Fission and Autophagy in the Normal and Diseased Heart
- 24 September 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Current Hypertension Reports
- Vol. 12 (6), 418-425
- https://doi.org/10.1007/s11906-010-0147-x
Abstract
Sustained hypertension promotes structural, functional and metabolic remodeling of cardiomyocyte mitochondria. As long-lived, postmitotic cells, cardiomyocytes turn over mitochondria continuously to compensate for changes in energy demands and to remove damaged organelles. This process involves fusion and fission of existing mitochondria to generate new organelles and separate old ones for degradation via autophagy. Autophagy is a lysosome-dependent proteolytic pathway capable of processing cellular components, including organelles and protein aggregates. Autophagy can be either nonselective or selective and contributes to remodeling of the myocardium under stress. Fission of mitochondria, loss of membrane potential, and ubiquitination are emerging as critical steps that direct selective autophagic degradation of mitochondria. This review discusses the molecular mechanisms controlling mitochondrial dynamics, including fission, fusion, transport, and degradation. Furthermore, it examines recent studies revealing the importance of these processes in normal and diseased heart.Keywords
This publication has 50 references indexed in Scilit:
- PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagyThe Journal of cell biology, 2010
- Drp-1-Dependent Division of the Mitochondrial Network Blocks Intraorganellar Ca2+ Waves and Protects against Ca2+-Mediated ApoptosisMolecular Cell, 2004
- Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma CellsCancer Research, 2004
- Cardiac-Specific Induction of the Transcriptional Coactivator Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Promotes Mitochondrial Biogenesis and Reversible Cardiomyopathy in a Developmental Stage-Dependent MannerCirculation Research, 2004
- Two Mitofusin Proteins, Mammalian Homologues of FZO, with Distinct Functions Are Both Required for Mitochondrial FusionThe Journal of Biochemistry, 2003
- Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosolThe Journal of cell biology, 2003
- Bioenergetic remodeling of heart during treatment of spontaneously hypertensive rats with enalaprilAmerican Journal of Physiology-Heart and Circulatory Physiology, 2002
- The human dynamin‐related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter‐membrane spaceFEBS Letters, 2002
- Mitochondrial filaments and clusters as intracellular power-transmitting cablesTrends in Biochemical Sciences, 2001
- A Human Dynamin-related Protein Controls the Distribution of MitochondriaThe Journal of cell biology, 1998