Calcium and Potassium Channels in Experimental Subarachnoid Hemorrhage and Transient Global Ischemia
Open Access
- 3 December 2012
- journal article
- review article
- Published by Hindawi Limited in Stroke Research and Treatment
- Vol. 2012, 1-8
- https://doi.org/10.1155/2012/382146
Abstract
Healthy cerebrovascular myocytes express members of several different ion channel families which regulate resting membrane potential, vascular diameter, and vascular tone and are involved in cerebral autoregulation. In animal models, in response to subarachnoid blood, a dynamic transition of ion channel expression and function is initiated, with acute and long-term effects differing from each other. Initial hypoperfusion after exposure of cerebral vessels to oxyhemoglobin correlates with a suppression of voltage-gated potassium channel activity, whereas delayed cerebral vasospasm involves changes in other potassium channel and voltage-gated calcium channels expression and function. Furthermore, expression patterns and function of ion channels appear to differ between main and small peripheral vessels, which may be key in understanding mechanisms behind subarachnoid hemorrhage-induced vasospasm. Here, changes in calcium and potassium channel expression and function in animal models of subarachnoid hemorrhage and transient global ischemia are systematically reviewed and their clinical significance discussed.Keywords
This publication has 93 references indexed in Scilit:
- Expressional Changes in Cerebrovascular Receptors after Experimental Transient Forebrain IschemiaPLOS ONE, 2012
- Endothelial SKCa and IKCa Channels Regulate Brain Parenchymal Arteriolar Diameter and Cortical Cerebral Blood FlowJournal of Cerebral Blood Flow & Metabolism, 2010
- Reduced Ca2+ Spark Activity after Subarachnoid Hemorrhage Disables BK Channel Control of Cerebral Artery ToneJournal of Cerebral Blood Flow & Metabolism, 2010
- Time trends in outcome of subarachnoid hemorrhageNeurology, 2010
- Dihydropyridine-Insensitive Calcium Currents Contribute to Function of Small Cerebral ArteriesJournal of Cerebral Blood Flow & Metabolism, 2010
- Oxyhemoglobin-Induced Expression of R-Type Ca 2+ Channels in Cerebral ArteriesStroke, 2008
- KATP channel expression and pharmacological in vivo and in vitro studies of the KATP channel blocker PNU‐37883A in rat middle meningeal arteriesBritish Journal of Pharmacology, 2008
- KIR channels function as electrical amplifiers in rat vascular smooth muscleThe Journal of Physiology, 2008
- Voltage-dependent calcium channels of dog basilar arteryThe Journal of Physiology, 2007
- Inhibition of T-Type Calcium Channels Protects Neurons from Delayed Ischemia-Induced DamagePublished by American Society for Pharmacology & Experimental Therapeutics (ASPET) ,2005