Fetal Alcohol Exposure and Effects of LHRH and PMA on LHβ‐mRNA Expression in the Female Rat
- 1 November 1991
- journal article
- Published by Wiley in Alcohol: Clinical and Experimental Research
- Vol. 15 (6), 1031-1035
- https://doi.org/10.1111/j.1530-0277.1991.tb05206.x
Abstract
Fetal alcohol exposure (FAE) is associated with a variety of physiological and behavioral dysfunctions. Effects of FAE on reproduction have been described that include delayed puberty, altered gonadotrophin secretion and steroidogenesis, and altered sexual behavior. Earlier work suggested that pituitary function was compromised in adult fetal alcohol-exposed female rats. This study examined the effects of LHRH and PMA in vitro on LH beta-mRNA expression in pituitary fragments from FAE animals; a separate experiment examined the effects of estradiol-17 beta on LH beta-mRNA under similar conditions. The results indicate that the pituitary glands of FAE females have a reduced ability to respond to these three stimuli. The reason for this reduced responsiveness to LHRH, PMA, and estradiol-17 beta is not clear, but the alterations suggest that LH synthesis is impeded following fetal ethanol exposure.Keywords
This publication has 42 references indexed in Scilit:
- LHRH and LH in peripubertal female rats following prenatal and/or postnatal ethanol exposureLife Sciences, 1989
- Prenatal Ethanol Exposure Alters Steroidogenic Enzyme Activity in Newborn Rat TestesAlcohol: Clinical and Experimental Research, 1989
- Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionAnalytical Biochemistry, 1987
- Inositol Trisphosphate And Diacylglycerol: 2 Interacting 2Nd MessengersAnnual Review of Biochemistry, 1987
- Effect of Prenatal Alcohol Exposure on Sexual Maturation of Female Rat OffspringNeuroendocrinology, 1986
- Turnover of Inositol Phospholipids and Signal TransductionScience, 1984
- Regulation of pituitary gonadotropin-releasing hormone receptors by pulsatile gonadotropin-releasing hormone injections in male rats. Modulation by testosterone.JCI Insight, 1984
- Growth, Enzymes and Hormonal Changes in Offspring of Alcohol‐Fed RatsPublished by Wiley ,1984
- Estradiol regulates mRNAs encoding precursors to rat lutropin (LH) and follitropin (FSH) subunitsBiochemical and Biophysical Research Communications, 1983
- Effect of Intraventricular Infusion of Catecholamines on Luteinizing Hormone Release in Ovariectomized and Ovariectomized, Steroid-Primed RatsNeuroendocrinology, 1979