Risk of Cancer in Patients Hospitalized With Fatty Liver
- 1 April 2003
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Clinical Gastroenterology
- Vol. 36 (4), 356-359
- https://doi.org/10.1097/00004836-200304000-00015
Abstract
To examine the risk of cancer in patients with fatty liver. The relation between liver disease, including fatty liver, and cancer risk is poorly understood. Using the population-based National Registry of Patients, we examined the incidence of cancer in 7,326 patients discharged with a diagnosis of fatty liver from a Danish hospital during 1977-1993. Patients with a prior diagnosis of liver cirrhosis were excluded. We identified cancers through the Danish Cancer Registry. The expected number of cancers was estimated from national age-, sex-, and site-specific incidence rates. Overall, 523 cancers were diagnosed during 47,594 person-years of follow-up, yielding a 1.7-fold increased risk (95% confidence interval, 1.6-1.9) compared with the Danish general population. The risk of primary liver cancer was markedly elevated in patients with alcoholic as well as nonalcoholic fatty liver with a standardized incidence ratio of 9.5 (95% confidence interval, 5.7-14.8) and 4.4 (95% confidence interval, 1.2-11.4), respectively. Patients with alcoholic fatty liver also had substantially increased risks of several types of cancer associated with alcohol and tobacco use (cancers of the lung, pharynx, larynx, esophagus, and stomach) and a moderately increased risk for cancers of the colon and breast. Among patients with nonalcoholic fatty liver, an increased risk of some alcohol- and tobacco-related cancers was seen, and there was also an increased risk of colon and pancreas cancer. Patients discharged with a diagnosis of fatty liver have an increased risk of cancer, in particular liver cancer, most prominently among patients with alcoholic fatty liver.Keywords
This publication has 14 references indexed in Scilit:
- Prevalence of and Risk Factors for Hepatic Steatosis in Northern ItalyAnnals of Internal Medicine, 2000
- Fatty Liver and Nonalcoholic Steatohepatitis. Where Do We Stand and Where Are We Going?Digestive Diseases, 1999
- Risk of liver and other types of cancer in patients with cirrhosis: A nationwide cohort study in DenmarkJournal of Hepatology, 1998
- Alcohol and Breast Cancer in WomenJAMA, 1998
- Cancer and diabetes ‐ a follow‐up study of two populationbased cohorts of diabetic patientsJournal of Internal Medicine, 1997
- Clinical hepatology: Profile of an urban, hospital-based practicJournal of Hepatology, 1996
- Obesity and cancer risk: a danish record-linkage studyEuropean Journal of Cancer, 1994
- Alcoholism and liver cirrhosis in the etiology of primary liver cancerInternational Journal of Cancer, 1992
- Incidence of parenchymal liver diseases in Denmark, 1981 to 1985: Analysis of hospitalization registry dataJournal of Hepatology, 1991
- Liver in obesity.Gut, 1985