Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution
- 30 April 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 303 (5912), 35-40
- https://doi.org/10.1038/303035a0
Abstract
The influenza virus neuraminidase glycoprotein is a tetramer with a box-shaped head, 100 .times. 100 .times. 60 .ANG., attached to a slender stalk. The three-dimensional structure of neuraminidase heads shows that each monomer is composed of 6 topologically identical .beta.-sheets arranged in a propeller formation. The tetrameric enzyme has circular 4-fold symmetry stabilized in part by metal ions bound on the symmetry axis. Sugar residues are attached to 4 of the 5 potential glycosylation sequences and, in one case, contribute to the interaction between subunits in the tetramer.This publication has 47 references indexed in Scilit:
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