Brachial Blood Pressure–Independent Relations Between Radial Late Systolic Shoulder-Derived Aortic Pressures and Target Organ Changes
- 1 April 2012
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 59 (4), 885-892
- https://doi.org/10.1161/hypertensionaha.111.187062
Abstract
Central aortic blood pressure (BP; BPc) predicts outcomes beyond brachial BP. In this regard, the application of a generalized transfer function (GTF) to radial pulse waves for the derivation of BPc is an easy and reproducible measurement technique. However, the use of the GTF may not be appropriate in all circumstances. Although the peak of the second shoulder of the radial waveform (P2) is closely associated with BPc, and, hence, BPc may be assessed without the need for a GTF, whether P2-derived BPc is associated with adverse cardiovascular changes independent of brachial BP is uncertain. Thus, P2- and GTF-derived aortic BPs were assessed using applanation tonometry and SphygmoCor software. Left ventricular mass was indexed for height 1.7 (n=678) and carotid intima-media thickness (IMT; n=462) was determined using echocardiography and vascular ultrasound. With adjustments for nurse-derived brachial pulse pressure (PP), P2-derived central PP was independently associated with left ventricular mass indexed for height 1.7 (partial r =0.18; P r =0.40; P 1.7 : partial r =0.17, P r =0.37, P r =−0.21 to 0.05). Twenty-four–hour, day, and night PP-target organ relations did not survive adjustments for nurse-derived brachial BP. In conclusion, central PP derived from P2, which does not require a GTF, is associated with cardiovascular target organ changes independent of brachial BP. Thus, when assessing adverse cardiovascular effects of aortic BP independent of brachial BP, P2-derived measures may complement GTF-derived measures of aortic BP.Keywords
This publication has 34 references indexed in Scilit:
- Ethnic Differences in Arterial Wave Reflections and Normative Equations for Augmentation IndexHypertension, 2011
- Relationship Between Urinary Salt Excretion and Pulse Pressure and Central Aortic Hemodynamics Independent of Steady State Pressure in the General PopulationHypertension, 2010
- Left Ventricular MassHypertension, 2010
- Wave Reflection and Arterial Stiffness in the Prediction of 15-Year All-Cause and Cardiovascular MortalitiesHypertension, 2010
- Nurse-recorded auscultatory blood pressure at a single visit predicts target organ changes as well as ambulatory blood pressureJournal Of Hypertension, 2009
- Is prehypertension an independent predictor of target organ changes in young-to-middle-aged persons of African descent?Journal Of Hypertension, 2008
- Pulsatile but Not Steady Component of Blood Pressure Predicts Cardiovascular Events in Coronary PatientsHypertension, 2008
- Arterial transfer functions and the reconstruction of central aortic waveforms: myths, controversies and misconceptionsJournal Of Hypertension, 2008
- Noninvasive Assessment of Local Pulse PressureHypertension, 2005
- Effect of non-invasive calibration of radial waveforms on error in transfer-function-derived central aortic waveform characteristicsClinical Science, 2004