Recent endemic coronavirus infection is associated with less-severe COVID-19
Top Cited Papers
- 4 January 2021
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 131 (1)
- https://doi.org/10.1172/jci143380
Abstract
Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal “common cold,” and these eCoVs share extensive sequence homology with human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we show that individuals with as compared to without a relatively recent documented eCoV were tested at greater frequency for respiratory infections but had similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less severe coronavirus disease-2019 (COVID-19) illness. Our observations suggest that pre-existing immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.Keywords
Funding Information
- National Institutes of Health (HL-135756)
- National Institutes of Health (AI-145661)
- National Institutes of Health (AI-052074)
- National Institutes of Health (GM-122876)
This publication has 21 references indexed in Scilit:
- Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, ChinaJAMA Internal Medicine, 2020
- Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020Morbidity and Mortality Weekly Report (MMWR), 2020
- Clinical and immunological features of severe and moderate coronavirus disease 2019JCI Insight, 2020
- Viral dynamics in mild and severe cases of COVID-19The Lancet Infectious Diseases, 2020
- Cyberspace Mimic DefensePublished by Springer Science and Business Media LLC ,2020
- Integrative Physiology of PneumoniaPhysiological Reviews, 2018
- Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumoniaJCI Insight, 2018
- Community-Acquired Pneumonia Requiring Hospitalization among U.S. AdultsThe New England Journal of Medicine, 2015
- The time course of the immune response to experimental coronavirus infection of manEpidemiology and Infection, 1990