Thrombopoietin Induces Phosphoinositol 3-Kinase Activation through SHP2, Gab, and Insulin Receptor Substrate Proteins in BAF3 Cells and Primary Murine Megakaryocytes
Open Access
- 1 January 2001
- journal article
- Published by Elsevier BV
- Vol. 276 (4), 2494-2502
- https://doi.org/10.1074/jbc.m002633200
Abstract
No abstract availableThis publication has 42 references indexed in Scilit:
- Interleukin-6 Inhibits Transforming Growth Factor-β-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 PathwaysPublished by Elsevier BV ,1999
- Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07eOncogene, 1999
- Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase AktScience, 1997
- Protein Kinase C andc-mycGene Activation Pathways in Thrombopoietin Signal TransductionBiochemical and Biophysical Research Communications, 1997
- Expression of Dominant Negative Mutant SHPTP2 Attenuates Phosphatidylinositol 3′-Kinase Activity via Modulation of Phosphorylation of Insulin Receptor Substrate-1Published by Elsevier BV ,1996
- TPO/c-mpl Ligand Induces Tyrosine Phosphorylation of Multiple Cellular Proteins Including Proto-oncogene Products, Vav and c-Cbl, and Ras Signaling MoleculesBiochemical and Biophysical Research Communications, 1995
- Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3-Kinase ActivityPublished by Elsevier BV ,1995
- Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 DomainsJournal of Biological Chemistry, 1995
- Thrombocytopenia in c-mpl-deficient miceScience, 1994
- Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietinNature, 1994