Norepinephrine evokes a marked Mg2+ efflux from liver cells
- 20 August 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 269 (1), 37-40
- https://doi.org/10.1016/0014-5793(90)81113-3
Abstract
The addition of norepinephrine to perfused rat livers and to collagenase isolated hepatocytes induced a marked and dose-dependent magnesium efflux. The addition of β-adrenergic receptor antagonists, but not α-antagonists, completely blocked the Mg2+ efflux. The Mg2+ efflux could also be induced by forskolin and by permeable cAMP analogues. By contrast, the addition of carbachol or vasopressin induced a Mg2+ influx into isolated hepatocytes. These results indicate that a significant Mg2+ efflux from liver cells can be induced through the β-adrenergic receptors and that it is mediated through the cytosolic cAMP levelsKeywords
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