Usefulness of immunohistochemistry in delineating renal spindle cell tumours. A retrospective study of 31 cases
- 30 April 2004
- journal article
- research article
- Published by Wiley in Histopathology
- Vol. 44 (5), 462-471
- https://doi.org/10.1111/j.1365-2559.2004.01868.x
Abstract
To assess the usefulness of immunohistochemistry in delineating tumour diagnoses on a series of morphologically diagnosed renal spindle cell tumours (RSCTs).Formalin-fixed paraffin-embedded tissues from 31 morphologically diagnosed tumours were reinterpreted in light of newly obtained immunohistochemical information. By morphology, six had originally been classified as sarcomatoid carcinoma, five as spindle cell tumour (NOS), four as sarcoma (NOS), three as leiomyoma, three as leiomyosarcoma, and one each as fibrous polyp, hamartoma, neurilemmoma, mesoblastic nephroma, medullary fibroma, angiomyolipoma, haemangiopericytoma, malignant rhabdoid tumour, malignant Triton tumour, and carcinosarcoma. The application of immunohistochemistry verified the original diagnosis in 18 cases (18/31, 58%), confirming the diagnosis of sarcomatoid renal carcinoma (4/6), leiomyoma (2/3), leiomyosarcoma (3/3), sarcoma (NOS) (2/4), carcinosarcoma (1/1), malignant rhabdoid tumour (1/1), malignant Triton tumour (1/1), fibrous polyp (1/1), mesoblastic nephroma (1/1), hamartoma (1/1), and angiomyolipoma (1/1). Different tumour designations were suggested in 13 cases (13/31, 42%), including carcinosarcoma, sarcoma (NOS), leiomyosarcoma, solitary fibrous tumour, monomorphic/biphasic angiomyolipoma, endometrial stromal tumour, and congenital mesoblastic nephroma.Our data indicate that although morphology is most important in formulating the initial differential diagnosis, the addition of immunohistochemistry is vital in arriving at the correct classification of RSCTs.Keywords
This publication has 34 references indexed in Scilit:
- Large Solitary Fibrous Tumor of the KidneyThe American Journal of Surgical Pathology, 2001
- Utility of CD10 in Distinguishing between Endometrial Stromal Sarcoma and Uterine Smooth Muscle Tumors: An Immunohistochemical Comparison of 34 CasesLaboratory Investigation, 2001
- Primary Renal Synovial SarcomaThe American Journal of Surgical Pathology, 2000
- Paraffin-Section Detection of CD10 in 505 Nonhematopoietic NeoplasmsAmerican Journal of Clinical Pathology, 2000
- Detection of the ETV6-NTRK3 Chimeric RNA of Infantile Fibrosarcoma/Cellular Congenital Mesoblastic Nephroma in Paraffin-Embedded Tissue: Application to Challenging Pediatric Renal Stromal TumorsLaboratory Investigation, 2000
- Solitary Fibrous Tumors of Soft TissueThe American Journal of Surgical Pathology, 1995
- Expression of CD34 by Solitary Fibrous Tumors of the Pleura, Mediastinum, and LungThe American Journal of Surgical Pathology, 1994
- Solitary Fibrous Tumor of the OrbitThe American Journal of Surgical Pathology, 1994
- Localized Benign and Malignant Fibrous Tumors of the PleuraThe American Journal of Surgical Pathology, 1989
- Benign Fibroepithelial Polyp of the Renal PelvisBJU International, 1982