Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block
Open Access
- 1 March 2017
- journal article
- research article
- Published by SAGE Publications in Journal of Pharmacology and Pharmacotherapeutics
- Vol. 8 (1), 3-7
- https://doi.org/10.4103/jpp.jpp_109_16
Abstract
Objective: To compare the effect of addition of fentanyl and clonidine as adjuvants to bupivacaine and lignocaine in peribulbar block. Methods: The study was conducted on 105 adult patients of either sex, of ASA grade I and II undergoing ophthalmic surgeries. Patients were randomly divided into 3 groups of 35 each. All the patients were given peribulbuar block with 5ml lignocaine 2% +3 ml bupivacaine 0.5% +1 ml hyaluronidase (250 IU). In addition to this 1 ml normal saline was added to Group S, 25 μg fentanyl to Group F and 25 μg clonidine to Group C. Onset and duration of globe and lid akinesia, duration of sensory blockage and analgesia, hemodynamic parameters, number of rescue analgesic and visual analogue score were recorded. Results: The mean time of onset of globe and lid akinesia was significantly faster in group F and group C compared to group S, mean duration of globe and lid akinesia was longer in Group F (207.71 + 13.54 and 143.14 + 7.86 min) and group C (213.52 + 14.52 and 162.06 + 17.1 min) compared to group S (117.78 + 10.42 and 87.64 + 9.76 min). The mean duration of analgesia was significantly longer in group F (217.71 + 12.67) and C (258.82 + 14.50 min) as compared to group S (131.39 + 9.63 min). Conclusion: Addition of fentanyl or clonidine as adjuvant to local anaesthetic in peribulbar block provides faster onset and prolonged analgesia compared to local anaesthetic alone.Keywords
This publication has 25 references indexed in Scilit:
- Peribulbar Versus Retrobulbar Anaesthesia for Cataract SurgeryAnesthesia & Analgesia, 2008
- Brainstem anaesthesia after retrobulbar block: A rare cause of coma presenting to the emergency departmentEmergency Medicine Australasia, 2006
- Comparison of fentanyl–bupivacaine or midazolam–bupivacaine mixtures with plain bupivacaine for caudal anaesthesia in childrenPediatric Anesthesia, 2003
- Peribulbar versus Retrobulbar Anesthesia for Ophthalmic SurgeryAnesthesiology, 2001
- Fentanyl Improves Analgesia but Prolongs the Onset of Axillary Brachial Plexus Block by Peripheral MechanismAnesthesia & Analgesia, 2000
- The influence of sufentanil and/or clonidine on the duration of analgesia after a caudal block for hypospadias repair surgery in childrenEuropean Journal of Anaesthesiology, 2000
- Use of clonidine as a component of the peribulbar block in patients undergoing cataract surgeryRegional Anesthesia & Pain Medicine, 1999
- Peripheral Mechanisms of Opioid AnalgesiaAnesthesia & Analgesia, 1993
- Clonidine Enhances the Effects of Lidocaine on C-Fiber Action PotentialAnesthesia & Analgesia, 1992
- Regional anaesthesia for 12,000 cataract extraction and intraocular lens implantation proceduresCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1988